New Experimental Drug Reverses Memory Loss due to Brain Injury

A study recently published in the Proceedings of the National Academy of Sciences found that ISRIB, a new drug, even when used weeks after the initial injury, can restore memory and learning functions in mice after traumatic brain injury (TBI).


With almost two million TBI victims in the U.S. each year, the new drug offers a lot of hope for treatment where other drugs have failed. Since TBI can also cause Alzheimer’s and other types of dementia, ISRIB has the potential to treat these diseases as well.

In the study, mice with focal contusions, which hinders spatial memory, and mice with concussive brain injuries, which tampers with memory capabilities, were both aided by ISRIB. Both types were tested in various abilities, including maze solving and swimming, before and after drug doses. The mice with TBIs, who struggled with the tests initially,  performed just as well as normal mice after receiving treatment and kept their abilities and memory even when only a trace of ISRIB remained in the body.


The drug works by inhibiting Integrated Stress Response, or ISR, which reduces the speed of DNA translation after an injury. When ISRIB blocks ISR it allows DNA translation to resume normally. However, scientists are are still investigating the mechanism behind ISRIB’s action and are unsure why this aids in memory retention and brain repair at the moment.

Despite the promise ISRIB offers many more trials and tests lie ahead before it can be used to treat human patients but researchers are optimistic about its future.


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